Table 2.
Association between nausea and change in miRNA expression (log 2) between week 0 and week 2
| Unadjusted | Adjusteda | |||||||
|---|---|---|---|---|---|---|---|---|
| miRNA (n = 160) | Week 0 (SD) | Week 2 (SD) | Delta week 0 week 2 (SD) | Nausea week 2 (n = 159) | β | P valueb | β | P valueb |
| miR20b-5p | 9.09 (0.64) | 9.23 (0.6) | 0.14 (0.59) | 3.40 (3.94) | −0.278 | .009 | −0.262 | .011 |
| miR106a-5p | 7.98 (0.71) | 8.14 (0.67) | 0.17 (0.68) | −0.276 | .009 | −0.248 | .011 | |
| miR20a-5p | 11.49 (0.57) | 11.65 (0.57) | 0.16 (0.57) | −0.264 | .009 | −0.266 | .011 | |
| miR17-5p | 11.52 (0.49) | 11.65 (0.47) | 0.13 (0.48) | −0.268 | .009 | −0.248 | .011 | |
| miR185-5p | 12.85 (0.46) | 12.96 (0.45) | 0.11 (0.42) | −0.253 | .009 | −0.238 | .027 | |
| miR103a-3p | 13.87 (0.37) | 13.96 (0.35) | 0.1 (0.32) | −0.231 | .019 | −0.209 | .039 | |
| miR103b | 13.87 (0.37) | 13.96 (0.35) | 0.1 (0.32) | −0.231 | .019 | −0.209 | .039 | |
| miR1301-3p | 7.26 (0.53) | 7.13 (0.49) | −0.13 (0.56) | 0.217 | .03 | 0.201 | .05 | |
| miR182-5p | 11.7 (0.69) | 11.83 (0.69) | 0.13 (0.55) | −0.217 | .03 | −0.181 | .028 | |
| miR15b-5p | 11.53 (0.62) | 11.71 (0.58) | 0.16 (0.65) | −0.211 | .008 | −0.17 | .034 | |
| miR93-5p | 12.02 (0.45) | 12.15 (0.43) | 0.13 (0.41) | −0.203 | .041 | −0.186 | .077 | |
| miR660-5p | 6.57 (0.62) | 6.74 (0.58) | 0.17 (0.64) | −0.200 | .041 | −0.21 | .013 | |
Abbreviation: miRNA, microRNA.
False discovery rate (0.05) correction.
aAge and gender.
bFalse Discovery Rate (0.05) correction for multiple comparisons.