Table 3.

Univariate and multivariate analyses of factors associated with OS after the diagnosis of AH-MCL

Variable	n	Events	Univariate*			Multivariate†
			HR	95% CI	P	HR	95% CI	P
Age, y	183	115	1.02	1-1.05	.02
WBC, ×109/L	177	111	1.01	1-1.01	<.001	1.00	1.00-1.01	.40
Hemoglobin, g/dL	178	111	0.85	0.78-0.92	<.001
Platelet count, ×109/L	178	111	1.00	0.99-1.00	<.001
LDH, IU/L	176	110	1.00	1.00-1.00	.003
β2-microglobulin, mg/L	112	70	1.13	1.06-1.20	<.001
Ki-67, %	161	101	1.02	1.01-1.02	<.001
AH-MCL category					<.001
AH-DN‡	108	61	1.00	1.00-1.00
AH-t	75	54	2.15	1.49-3.13		3.62	2.03-6.46	<.001
AH-MCL subcategory					<.001
Blastoid-DN	93	53	1.00	1.00-1.00
Pleomorphic-DN	15	8	1.17	0.56-2.47
AH-t	75	54	2.20	1.49-3.24
PS-ECOG					<.001
0‡	40	18	1.00	1.00-1.00
1	103	63	1.40	0.83-2.37		2.80	1.40-5.60	.004
2	27	21	3.34	1.77-6.30		5.83	2.46-13.81	<.001
3	5	5	7.00	2.54-19.31		4.82	1.15-20.29	.032
4	6	6	40.6	14.30-115.28		15.7	4.16-59.51	<.001
B symptoms					.007
No‡	147	90	1.00	1.00-1.00
Yes	35	24	1.86	1.18-2.93		1.11	0.55-2.23	.77
CNS involvement					.02
No‡	175	109	1.00	1.00-1.00
Yes	8	6	2.59	1.12-5.98		2.36	0.64-8.75	.19
LDH (above the ULN), IU/L					<.001
No	96	50	1.00	1.00-1.00
Yes	79	60	2.35	1.59-3.48
Age ≥72 y					<.001
No‡	141	85	1.00	1.00-1.00
Yes	42	30	2.00	1.31-3.06		1.97	1.18-3.27	.009
Ki-67 ≥50%					<.001
No‡	33	14	1.00	1.00-1.00
Yes	128	87	3.77	2.09-6.81		2.49	1.32-4.69	.005
LDH ≥1519 IU/L					<.001
No‡	159	93	1.00	1.00-1.00
Yes	17	17	4.50	2.61-7.77		1.52	0.59-3.93	.39
β2-microglobulin ≥4 mg/L					.006
No	73	41	1.00	1.00-1.00
Yes	39	29	1.96	1.20-3.20
Hemoglobin ≥14 g/dL					.004
No‡	149	98	1.00	1.00-1.00
Yes	29	13	0.44	0.24-0.78		0.89	0.44-1.82	.75
Platelet count ≥63 × 109/L					<.001
No‡	17	17	1.00	1.00-1.00
Yes	161	94	0.24	0.14-0.42		0.39	0.19-0.79	.009
Response to first-line treatment					<.001
No CR	72	55	1.00	1.00-1.00
CR	90	45	0.29	0.19-0.43

Bold values are statistically significant.

^*Factors not significant in univariate analysis are not shown: absolute monocyte count, absolute lymphocyte count, sex, histology type blastoid or pleomorphic, leukemic phase, bone marrow involvement, SOX-11, light chain type, and type of first-line treatment given.

^†Variables with >25% of missing values were excluded from this analysis.

^‡Reference in multivariate analysis.