Table 4.
Multivariate Cox models for individual late effects in AYA patients with AML after ablative HCT
| Late effect/variable | n | HR | 95% CI | P |
|---|---|---|---|---|
| SN | ||||
| Conditioning regimen | .696 | |||
| Non-TBI MAC | 435 | 1 | ||
| TBI MAC | 383 | 0.82 | 0.31-2.20 | |
| Disease status at HCT | .049 | |||
| CR1 | 571 | 1 | ||
| CR2+ | 247 | 2.70 | 1.00-7.27 | |
| cGVHD | ||||
| No | 368 | 1 | ||
| Yes | 450 | 1.28 | 0.46-3.55 | .637 |
| AVN | ||||
| Conditioning regimen | .178 | |||
| Non-TBI MAC | 422 | 1 | ||
| TBI MAC | 367 | 1.48 | 0.84-2.64 | |
| cGVHD | .006 | |||
| No | 354 | 1 | ||
| Yes | 435 | 2.49 | 1.29-4.76 | |
| Cataracts | ||||
| Conditioning regimen | ||||
| Non-TBI MAC | 432 | 1 | ||
| TBI MAC | 379 | 4.98 | 2.42-10.24 | <.0001 |
| TBI MAC 550-1200 cGy | 23 | 2.08 | 0.26-16.45 | .486 |
| TBI MAC ≥1200 cGy | 356 | 5.16 | 2.51-10.63 | <.0001 |
| Disease status at HCT | .049 | |||
| CR1 | 567 | 1 | ||
| CR2+ | 244 | 1.74 | 1.00-3.03 | |
| cGVHD | .0006 | |||
| No | 363 | 1 | ||
| Yes | 448 | 3.22 | 1.65-6.29 | |
| Diabetes mellitus | ||||
| Conditioning regimen | .202 | |||
| Non-TBI MAC | 340 | 1 | ||
| TBI MAC | 314 | 1.82 | 0.72-4.58 | |
| cGVHD | .030 | |||
| No | 300 | 1 | ||
| Yes | 354 | 3.36 | 1.12-10.04 | |
| Gonadal dysfunction | ||||
| Conditioning regimen | .980 | |||
| Non-TBI MAC | 419 | 1 | ||
| TBI MAC | 365 | 0.99 | 0.60-1.64 | |
| Sex of recipient | .019 | |||
| Male | 437 | 1 | ||
| Female | 347 | 1.83 | 1.10-3.04 | |
| Disease status before HCT | .006 | |||
| CR1 | 544 | 1 | ||
| CR2+ | 240 | 2.02 | 1.22-3.35 | |
| Hypothyroidism | ||||
| Conditioning regimen | .367 | |||
| Non-TBI MAC | 426 | 1 | ||
| TBI MAC | 372 | 1.55 | 0.60-4.00 |