Table 1.
CNVs in CAD patient samples detected by both cytogenetic microarray assay and exome sequencing CNV analysis
| Major recurrent CNVs | Other CNVs* | Response to therapy (CAD5) | |||
|---|---|---|---|---|---|
| Samples | chr3 | chr12 | chr18 | ||
| CAD-1.06 | +3 | +12 | — | N/A | Partial remission |
| CAD-1.07 | +3 | — | +18 | N/A | No response |
| CAD-1.22 | +3 | — | +18 | — | Partial remission |
| CAD-1.23 | +3 | — | — | −7q31.2-q32.3 | Complete remission |
| CAD-1.24 | +3 | +12 | — | +21† | Partial remission |
| CAD-1.25 | +3† | — | — | +1q23.1-q31.3; +1q42.13-q44; −3p21.31-p21.2; −6q23.3-q24.1; −8p23.1-p21.1‡; −10q23.31‡ | Partial remission |
| CAD-1.26 | +3 | — | — | — | Complete remission |
| CAD-1.30 | +3 | — | +18 | −6q16.1‡ −8p21.3-p21.1‡ | Complete remission |
| CAD-1.31 | +3 | — | +18 | −2q37.3‡; +10q24.32‡ | No response |
| CAD-1.32 | — | — | — | — | Complete remission |
| CAD-1.34 | +3 | — | +18q | +14q12‡ | No response |
| CAD-1.37 | +3q | +12 | — | −8p23.3-p11.23‡ | Partial remission |
| CAD-2.02 | +3q | +12† | — | −8p23.3-p12; −8q11.1q12.1; -X | Complete remission |
| CAD-5§ | +3q | +12 | — | N/A | N/A |
| CAD-7§ | +3 | — | +18 | N/A | N/A |
N/A, not available.
*
CNVs detected by both cytogenetic microarrays and exome sequencing CNV analysis.
†
Almost entire chromosome.
‡
CNVs <3 Mb detected by both cytogenetic microarray assay and exome sequencing CNV analysis.
§
Analyzed by exome sequencing CNV analysis only.