Table 3.
Univariable analysis of PFS and OS by dichotomized (below vs above the ROC cutoff point) functional PET parameters in the validation and testing sets
| Univariable analysis of PFS | Univariable analysis of OS | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 5-y PFS (95% CI), % | Log-rank P | HR (95%CI) | NPV | PPV | 5-y OS (95% CI), % | Log-rank P | HR (95%CI) | NPV | PPV | ||
| Testing set | SUVmax | .164 | 0.6 (0.3-1.2) | 84 | 27 | .196 | 0.5 (0.2-1.4) | 89 | 19 | ||
| Low | 72 (58-81) | 81 (71-88) | |||||||||
| high | 80 (67-88) | 90 (78-96) | |||||||||
| MTV (mL) | .0005 | 3.4 (1.6-7.0) | 86 | 40 | .0001 | 4.4 (1.9-10) | 90 | 35 | |||
| Low | 83 (72-90) | 91 (83-95) | |||||||||
| High | 61 (44-74) | 65 (46-78) | |||||||||
| TLG | .0078 | 2.6 (1.3-5.6) | 86 | 31 | .0021 | 3.4 (1.5-7.8) | 90 | 29 | |||
| Low | 83 (72-90) | 90 (81-95) | |||||||||
| High | 65 (50-77) | 73 (57-84) | |||||||||
| MH | .0780 | 1.9 (0.9-3.9) | 84 | 29 | .1011 | 2.0 (0.9-4.4) | 87 | 22 | |||
| Low | 80 (69-88) | 88 (79-93) | |||||||||
| High | 69 (54-80) | 79 (65-88) | |||||||||
| Validation set | SUVmax | .0935 | 2.2 (0.9-5.6) | 83 | 32 | .0432 | 2.6 (0.99-6.9) | 86 | 32 | ||
| Low | 77 (63-86) | 79 (63-89) | |||||||||
| High | 67 (41-84) | 63 (34-82) | |||||||||
| MTV (mL) | .021 | 2.9 (1.1-7.3) | 89 | 28 | .0090 | 3.9 (1.3-11.8) | 93 | 26 | |||
| Low | 85 (67-93) | 92 (80-97) | |||||||||
| High | 66 (48-79) | 62 (41-77) | |||||||||
| TLG | .0632 | 2.2 (0.9-5.0) | 86 | 27 | .0107 | 3.1 (1.2-7.8) | 89 | 27 | |||
| Low | 82 (67-90) | 83 (65-92) | |||||||||
| High | 64 (41-80) | 63 (39-79) | |||||||||
| MH | .1547 | 1.8 (0.8-4.2) | 84 | 28 | .0433 | 2.5 (0.99-6.0) | 88 | 28 | |||
| Low | 80 (64-89) | 85 (74-92) | |||||||||
| High | 67 (47-81) | 56 (26-78) | |||||||||
Bold P values indicate statistically significant results (P < .05).