TABLE 1.

Most commonly used matrices for the growth of 3D cultures.

Matrix	Composition	Derivation	Applications
Matrigel®	collagen type IV, laminin, heparan sulfate proteoglycans, entactin/nidogen, and a number of growth factors	murine Englebreth-Holm-Swarm sarcoma tumors	3D cell culture
Collagen type I	collagen type I	rat tail	3D cell culture
HA hydrogel	hyaluronic acid	synthetic	3D cell culture; clinical applications
PEG hydrogel	polyethylene glycol (PEG) hydrogel supplemented with an RGD (Arg-Gly-Asp) peptide	synthetic	3D cell culture; clinical applications
PEG-4MAL hydrogel	PEG with maleimide groups at each terminus	synthetic	3D cell culture; clinical applications
Fibrin/laminin hydrogel	fibrin, laminin	synthetic	3D cell culture; clinical applications