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Effect of BAE (50–1000 mg kg−1 p.o.) and PGABA (10–100 mg kg−1 p.o.) on the vincristine-induced hypernociception (Randall–Sellito) in rats. (a, b) The time-course effect; (c, d) the bar graphs of the AUCs. ∗∗∗∗P < 0.0001 compared with the vehicle-treated group (2-way RM ANOVA followed by Dunnett's post hoc test). ++++P < 0.0001 compared with the vehicle-treated group (ordinary 1-way ANOVA followed by Turkey's post hoc test). Each data presented are mean ± S.E.M (n = 10).
