Figure 2.

The involvements of SIRT1/3 and AMPK in the RSV-induced cardioprotection against the development of DCM. SIRT1 and AMPK are the key downstream molecules of RSV, mediating various molecules and subsequently exerting cardioprotective effects such as antioxidative, antiapoptosis, and proautophagy in cardiomyocytes in high-glucose condition. Moreover, Sirt3, a mitochondrial Sirt member, is also shown to coregulate TFAM with SIRT1 and together contribute to a antimetabolic disorder effect eventually. Additionally, the relationship between RSV and Cav1/3 is also described in this picture.