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Spike glycoprotein of SARS-CoV is composed of two domains S1 and S2 separated by a protease cleavage site. The N-terminal domain has a signal peptide (SP) and a transmembrane domain (TM) is present at the C-terminus. Other regions are receptor binding domain (RBD), two heptad repeat (HR1 and HR2) sequences and putative fusion peptides named as fusion peptide (FP), internal fusion peptide (IFP) and pre transmembrane domain (PTM).
