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. 2007 Aug 6;53(7):348–387. doi: 10.1016/j.disamonth.2007.05.006

TABLE 2.

“BIODROME” key differentiating symptoms: avian influenza compared with seasonal flu and influenza-like illnesses/upper respiratory infections

Is it? Number of “+” indicates strength of association Avian Flu (H5N1) Seasonal Influenza (Flu) Upper Respiratory Infection Common Cold
Elevated temp +++/++++ ++ ++ +/−
Fever/chills ++++ ++++ ++++
Cough +++ +++ +++ +++
Shortness of breath ++++ +/− +/−
Chest discomfort +++ ++ ++
Sore throat +/− +++ +++ ++
Vomiting/nausea ++ + +
Diarrhea ++ + (young children) +/−
CNS/encephalopathy/seizures ++
Malaise/fatigue +++ +++ + +/−
Runny nose/watery eyes +/− + ++ +++
Headache/muscle ache +++ +++ ++ +/−
Young healthy at risk for serious illness +++ +/− +/−