Table 1.
Oligonucleotide Stability and Cellular Uptakea
| Backbone Chemistry | Nuclease Stability | Cellular Uptake | Charge |
|---|---|---|---|
| PO | ↓ | ↓ | — |
| PS | ↑ | ↓ | — |
| MP | ↑ | ↓↓ | Ø |
| PNA | ↑ | ↓↓ | Ø |
a
Key: (↓) low; (↓↓) very low; (↑) high; (—) negative; (Ø) neutral.
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