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Heat maps of SELDI-TOF MS profiles of single sheep sera at week 0 and weeks 3 and 9 p.i. with Fasciola hepatica. At each time-point the data are presented in rank order of increasing worm burden (sheep 12, 24, 16, 13, 22, 20 and 30). Heat maps show the validated biomarkers from the pH 9, pH 7 and organic wash fractions in the range 1.5–10 kDa (a), 7–30 kDa (b) and 30–150 kDa (c). Peaks are clustered using dendograms to reveal patterns of up-regulation (red) and down-regulation (green).
