Table 1.
AIS-PreTM-TMD motifs in selected examples of viral fusion proteins
| Protein a | Sequence b |
|---|---|
| HIV-1 Env | 658-QELLELDKWASLWNWFNITNWLWYIKLFIMIVGGLVGLRIVFAVLSVVNR-707 |
| SARS Co-S | 1181-DLQELGKYEQYIKWPWYVWLGFIAGLIAIVMVTILLCCMTSCCSCL-1226 |
| Ebola GP | 639-GDNDNWWTGWRQWIPAGIGVTGVIIAVIALFCICKFVF-676 |
| FIV Env | 760-GKTGIQQLQKWEDWVRWIGNIPQYLKGLLGGILGIGLGVLLLILCLPTLVD-810 |
| VSV-GP | 449-NPIDFVEGWFSSWKSSIASFFFIIGLIIGLFLVLRVGIYLYIKLK-493 |
a
Numbering based on the HIV-1 HXB2, Ebola Zaire, FIV Petuma, SARS-CoV Urbani and VSV Indiana, strains/serotypes.
b
Sequences in boxes and bold span, amphipathic-at-interface and hydrophobic-at-interface domains, respectively, as determined by WW algorithm. Underlined sequences in italics denote hydrophobic transmembrane sequences estimated according to KD algorithm. The range of each sequence has been inferred from plots displayed in Fig. 1 .