Table 1.
Association Between Demographic Variables at Birth and Clinical Events in the First Year of Life (Infections, Gastrointestinal Illnesses, Failure to Thrive, and Hospital Readmission) and the Development of Inflammatory Bowel Disease, at Any Age Among All Persons With Inflammatory Bowel Disease Compared to Controls
| Effect | Comparison | OR estimate | 95% Wald confidence limits | P value |
IBD |
P value | |
|---|---|---|---|---|---|---|---|
| Casea (n = 825) | Controla (n = 5999) | ||||||
| Infection year 1 | Yes vs no | 1.39 | 1.09, 1.79 | .01 | 90.3 | 87.6 | .03 |
| Socioeconomic status | |||||||
| Q1 | — | — | — | — | 14.79 | 17.57 | .05 |
| NF | NF vs Q1 | 0.76 | 0.37, 1.56 | .45 | 1.1 | 1.8 | — |
| Q2 | Q2 vs Q1 | 1.31 | 1.02, 1.68 | .36 | 23.52 | 21.72 | — |
| Q3 | Q3 vs Q1 | 1.09 | 0.84, 1.42 | .52 | 19.39 | 21.47 | — |
| Q4 | Q4 vs Q1 | 1.37 | 1.06, 1.77 | .02 | 24.36 | 21.94 | — |
| Q5 | Q5 vs Q1 | 1.35 | 1.01, 1.79 | .04 | 16.85 | 15.5 | — |
| Geography | Rural vs urban | 0.91 | 0.72, 1.15 | .45 | 38.9 | 37.3 | .18 |
| Apgar 1 min | 7+ vs <7 | 1.09 | 0.86, 1.39 | .46 | 88.12b | 86.73 | .2 |
| Apgar 5 min | 7+ vs <7 | 1.07 | 0.49, 2.33 | .87 | 99.03b | 98.8 | .56 |
| ICU admission | No vs yes | 1.06 | 0.63, 1.77 | .83 | 97.6 | 97.23 | .57 |
| Gestational age | — | 1.004 | 0.95, 1.06 | .88 | 39.4 | 39.4 | .88 |
| Birth weight | — | 1.000 | 1.000, 1.000 | .79 | 3451ˆ | 3444c | .76 |
| Readmitted in yr 1 | No vs yes | 1.21 | 0.94, .56 | .14 | 88.36 | 86.23 | .09 |
| Cesarean section | Yes vs no | 1.06 | 0.86, 1.32 | .57 | 14.18 | 14.07 | .93 |
| Maternal IBD | Yes vs no | 4.53 | 3.08, 6.67 | <.001 | 5.45 | 1.25 | <.001 |
| Hospitalized for GI | Yes vs no | 0.79 | 0.46, 1.36 | .39 | 2.18 | 2.90 | .24 |
ICU, intensive care unit; NF, not found; Q, quintile.
a
Data in case and control columns reflect % in each category unless otherwise specified.
b
Data for % with Apgar of 7+.
c
Data reflects grams.