Table 3.
Association Between Demographic Variables at Birth and Clinical Events in the First Year of Life (Infections, Gastrointestinal Illnesses, Failure to Thrive, and Hospital Readmission) and the Development of Ulcerative Colitis, at Any Age Among All Persons With Ulcerative Colitis Compared to Controls
| Effect | Comparison | OR estimate | 95% Wald confidence limits | P value |
|---|---|---|---|---|
| Infection year 1 | Yes vs No | 1.41 | 0.95, 2.08 | .09 |
| Socioeconomic status | ||||
| Q1 | NF vs Q1 | 1.20 | 0.48, 3.00 | .69 |
| Q2 | Q2 vs Q1 | 1.61 | 1.07, 2.41 | .02 |
| Q3 | Q3 vs Q1 | 1.51 | 0.996, 2.29 | .05 |
| Q4 | Q4 vs Q1 | 1.63 | 1.08, 2.46 | .02 |
| Q5 | Q5 vs Q1 | 1.71 | 1.09, 2.69 | .02 |
| Geography | Rural vs urban | 0.91 | 0.64, 1.29 | .6 |
| Apgar 1 min | 7+ vs <7 | 0.78 | 0.55, 1.11 | .17 |
| Apgar 5 min | 7+ vs <7 | 1.04 | 0.37, 2.89 | .95 |
| ICU admission | No vs yes | 1.31 | 0.48, 3.57 | .6 |
| Gestational age | — | 0.99 | 0.91, 1.08 | .84 |
| Birth weight | — | 1.000 | 1.000, 1.000 | .61 |
| Readmitted in year 1 | No vs yes | 1.25 | 0.84, 1.84 | .27 |
| Cesarean section | Yes vs no | 1.22 | 0.89, 1.69 | .22 |
| Maternal IBD | Yes vs no | 2.71 | 1.34, 5.51 | .01 |
| Hospitalized for GIa | Yes vs no | 0.87 | 0.41, 1.86 | .73 |
ICU, intensive care unit; NF, not found; Q, quintile.
a
Hospitalized for GI means hospitalized for any of gastrointestinal infections, gastrointestinal disease or abdominal pain in the first year of life.