Table 6.
Association Between Demographic Variables at Birth and Clinical Events in the First Year of Life (Infections, Gastrointestinal Illnesses, Failure to Thrive, and Hospital Readmission) and the Development of Inflammatory Bowel Disease, Among All Persons With Inflammatory Bowel Disease (n = 827) Compared to Sibling Controls (n = 994)
| Effect | Comparison | OR estimate | 95% Wald confidence limits | P value |
|---|---|---|---|---|
| Infection year 1 | 1 vs | 1.22 | 0.90, 1.66 | .19 |
| Q1 | NF vs Q1 | 1.83 | 0.18, 18.73 | .61 |
| Q2 | Q2 vs Q1 | 1.56 | 0.78, 3.13 | .21 |
| Q3 | Q3 vs Q1 | 1.37 | 0.64, 2.95 | .42 |
| Q4 | Q4 vs Q1 | 1.76 | 0.81, 3.81 | .15 |
| Q5 | Q5 vs Q1 | 1.06 | 0.43, 2.61 | .89 |
| Sex | Male vs female | 0.95 | 0.74, 1.22 | .71 |
| Age at diagnosisa | — | 1.28 | 1.22, 1.34 | <.001 |
| Geography | Rural vs urban | 0.53 | 0.24, 1.19 | .13 |
| Apgar 1 min | 7+ vs <7 | 1.33 | 0.90, 1.97 | .16 |
| Readmission 1 y | No vs Yes | 1.27 | 0.65, 2.45 | .48 |
| Cesarean section | Yes vs No | 1.21 | 0.66, 2.24 | .53 |
NF, not found; Q, quintile.
a
Age at diagnosis of IBD case compared to age of sibling at time of diagnosis.