Table 1.
Mortality (overall) and morbidity (after first SCT)
| n | % | |
|---|---|---|
| Causes of death (after 1–3 SCTs) | ||
| Infection | 15 | 10.0 |
| Viral | ||
| Adeno, EBV and CMV | 8 | |
| RSV | 1 | |
| Bacterial | 5 | |
| Fungal | 1 | |
| GvHD | 3 | 2.0 |
| Cardial/respiratory ECI | 2 | 1.4 |
| VOD (+parainfluenza III/enterocolitis) | 2 | 1.4 |
| DAH | 1 | 0.7 |
| Multiorgan failure ECI | 1 | 0.7 |
| Hurler (disease progression) | 4 | 2.7 |
| Morbidity after first SCT | ||
| Acute GvHD (n=146) | ||
| Grade I | 26 | 17.8 |
| Grade II | 15 | 10.3 |
| Grade III | 3 | 2.1 |
| Grade IV | 5 | 3.5 |
| Chronic GvHD (n=114a) | ||
| Limited | 6 | 4.1 |
| Extensive | 2 | 1.4 |
| VOD (n=134) | ||
| Pulmonary complications (ventilated) (n=132b) | 12 | 8.3 |
| IPS/DAH | 4 | 2.8 |
| Infection/ARDS | 7 | 4.8 |
| Pulmonary hypertension | 1 | 0.7 |
Abbreviations: ARDS=acute respiratory distress syndrome; CMV=cytomegalovirus; DAH=diffuse alveolar hemorrhage; ECI=e causa ignota (= of unknown origin); GvHD=graft-versus-host disease; IPS=idiopathic pneumonia syndrome; RSV=respiratory syncytial virus; SCT=stem cell transplantation; VOD=veno-occlusive disease.
aPatients at risk.
bFor 14 patients, data are missing.
Values with no significance are shown in bold type.