Table 2.
Univariate Analysis of Clinical Data and Laboratory Variables Before NIPPV in Relation to Clinical Outcome*
| Variables | Success (n = 14) | Failure (n = 6) | p Value |
|---|---|---|---|
| Age, yr | 54.2 ± 11.8 | 44.8 ± 18.2 | 0.353 |
| Presence of comorbidities, No. | 6 | 1 | 0.260 |
| Corticosteroid plus ribavirin starting date, d | 8.4 ± 9.7 | 4.3 ± 1.9 | 0.109 |
| Pulse steroid starting date, d | 8.9 ± 2.4 | 8.0 ± 2.6 | 0.494 |
| NIPPV starting date, d | 9.6 ± 3.8 | 9.3 ± 4.9 | 0.602 |
| APACHE II score | 5.2 ± 3.2 | 5.7 ± 2.3 | 0.718 |
| Risk of death, % | 6.5 ± 3.1 | 6.6 ± 2.1 | 0.511 |
| CXR score | 16.4 ± 6.7 | 21.5 ± 4.3 | 0.153 |
| iPAP, cm H2O | 12.1 ± 2.0 | 11.2 ± 1.0 | 0.397 |
| ePAP, cm H2O | 7.6 ± 2.1 | 6.5 ± 1.4 | 0.207 |
| Tidal volume, mL/kg | 8.3 ± 2.8 | 7.6 ± 3.4 | 0.718 |
| Duration of NIPPV, h | 83.5 ± 37.6 | 86.2 ± 68.5 | 0.904 |
| ICU stay, d | 3.1 ± 2.1 | 21.3 ± 21.2 | < 0.001 |
| Hospital stay, d | 29.6 ± 7.9 | 43.3 ± 19.3 | 0.062 |
| Mortality, No. | 2 | 1 | 0.891 |
| Hemoglobin, g/dL | 12.0 ± 1.5 | 12.3 ± 1.3 | 0.491 |
| Neutrophils, 109/L | 10.2 ± 6.1 | 10.9 ± 3.0 | 0.190 |
| Lymphocytes, 109/L | 0.43 ± 0.22 | 0.55 ± 0.30 | 0.202 |
| Platelets, 109/L | 223 ± 102 | 221 ± 81 | 0.863 |
| ALT, IU/L | 58 ± 55 | 56 ± 50 | 0.906 |
| CK, IU/L | 512 ± 1,018 | 335 ± 431 | 0.310 |
| LDH, IU/L | 416 ± 165 | 497 ± 179 | 0.815 |
*
Data are presented as mean ± SD unless otherwise indicated. Success = off NIPPV for ≥ 24 h and no endotracheal intubation. Failure = failed NIPPV and required endotracheal intubation. See Table 1 for expansion of abbreviations.