Fig. 3.

Inhibitory effects of antivirals on the viral replication of wild-type and lamivudine-resistant HBV. HepG2 cells were transiently transfected with wild-type (A) or lamivudine-resistant (B) HBV genome. Twenty-four hours after transfection, the cultures were treated with the indicated concentrations of lamivudine (LAM), adefovir (ADV) or cepharanthine hydrochloride (CH). After 6 days of treatment, viral DNA was extracted from the cultured cells and quantified by real-time quantitative PCR using a commercially available kit. The experiments were performed in triplicate, and the data are presented as the means ± S.D. of three independent experiments. **P < 0.01, *P < 0.05 compared with the no drug control group.