Table 2.
Results of CRP, PCT, and Cytokines According to Causal Microorganism and Bacteremia
| Cause |
Bacteremia |
|||||
|---|---|---|---|---|---|---|
| Biomarkers | No (n = 390) | Yes (n = 295) | P Value | No (n = 527) | Yes (n = 48) | P Value |
| CRP, mg/dL | 13.7 (6.95–21.85) | 18.1 (9.7–27.3) | < .0001 | 16.1 (8.8–24.1) | 23.3 (14.9–35.1) | .002a |
| PCT, ng/mL | 0.37 (0.15–1.56) | 0.86 (0.27–4.12) | < .00001 | 0.51 (0.18–2.24) | 4.54 (0.49–11.16) | < .00001b |
| TNF-α, pg/mL | 25 (15–41) | 27 (15–48) | NS | 26 (15–45) | 30.5 (18–67) | .04c |
| IL-1, pg/mL | 15 (3–33) | 16 (4–32) | NS | 16 (4–33) | 16.5 (3–33) | NS |
| IL-6, pg/mL | 71 (25–175) | 105 (42–300) | < .0001 | 95 (34–235) | 192 (79.5–568.5) | .004d |
| IL-10, pg/mL | 5 (0–15) | 6 (0–19) | NS | 5 (0–17) | 12 (1–38.5) | NS |
| IL-8, pg/mL | 8 (2–17) | 9 (3–22) | NS | 10 (3–20) | 5 (2–30.5) | NS |
Data are presented as median (interquartile range). AUC = area under the curve; CRP = C-reactive protein; NS = not significant; PCT = procalcitonin; TNF-α = tumor necrosis factor-α.
a
AUC, 0.7 (0.6–0.8); P < .001.
b
AUC, 0.7 (0.6–0.8); P < .0001.
c
AUC, 0.6 (0.5–0.7); P = .03.
d
AUC, 0.7 (0.6–0.7); P < .001.