Table 4.
Biomarkers and Cytokines According to Causal Microorganisms and Sepsis Status
| Biomarkers and Sepsis Status | NE | GPC | GNB | ATP | VIR | P Value |
|---|---|---|---|---|---|---|
| CRP | ||||||
| No sepsis | 13.5 (6–20) | 17.6 (5.1–30.2) | 13.8 (9.8–23.7) | 12.7 (7.6–19.1) | 4.9 (0.7–12.9) | NS |
| Sepsis | 12 (6.5–22.7) | 20.3 (12.2–28.2) | 18.5 (12.6–24.9) | 13.8 (7.5–24.3) | 12 (8.9–29.5) | < .05 |
| Severe sepsis/shock | 15.5 (8.4–23.4) | 20 (11.1–28.1) | 23.5 (10–32.8) | 11.3 (4–33.6) | 17.8 (14–21.6) | NS |
| PCT | ||||||
| No sepsis | 0.2 (0.1–0.6) | 0.7 (0.2–4.5) | 0.3 (0.1–1.1) | 0.2 (0.1–0.3) | 0.3 (0.2–0.4) | .004 |
| Sepsis | 0.3 (0.1–1.2) | 1.9 (0.7–4.1) | 0.6 (0.4–2.8) | 0.2 (0.1–0.5) | 0.1 (0.1–0.5) | < .0001 |
| Severe sepsis/shock | 0.8 (0.3–2.7) | 2.4 (0.8–9.1) | 0.7 (0.4–6) | 0.2 (0.2–0.6) | 1.2 (0.2–2.2) | .2 |
| TNF-α | ||||||
| No sepsis | 23 (13–41) | 35 (18–48) | 20 (11–58) | 23 (21–35) | 26.5 (18–35.5) | NS |
| Sepsis | 24 (14–34.5) | 29 (18–43) | 37 (13–52) | 26.5 (21–39) | 8 (8–13) | NS |
| Severe sepsis/shock | 29 (18–45) | 26 (16–48) | 37 (17–72) | 40 (36–128) | 18.5 (10–27) | NS |
| IL-1 | ||||||
| No sepsis | 10 (3–27) | 14 (3–34) | 12 (4–46) | 33 (5–50) | 14 (9–18) | NS |
| Sepsis | 17 (4–35) | 6.5 (2–19) | 22 (3–29) | 15.5 (4–26) | 2 (0–7) | NS |
| Severe sepsis/shock | 17 (2–37) | 18 (5–35) | 17.5 (6–36) | 22 (9–24) | 15.5 (13–18) | NS |
| IL- 6 | ||||||
| No sepsis | 66 (23–146) | 97 (29–225) | 71 (22–144) | 27.5 (17–77) | 54.5 (21–137.5) | NS |
| Sepsis | 65.5 (24.5–165.5) | 185 (92–380) | 79 (22–324) | 49.5 (39–79) | 39 (30–1549) | .005 |
| Severe sepsis/shock | 93 (30–273) | 150 (47–253) | 197 (69–1.288) | 166 (77–460) | 235.5 (66–405) | NS |
| IL-10 | ||||||
| No sepsis | 3 (0–9) | 2 (0–16) | 6 (0–9) | 7.5 (1–14) | 12 (1–28) | NS |
| Sepsis | 5 (0–12) | 2.5 (0–14) | 4 (0–15) | 1 (0–15) | 18 (0–27) | NS |
| Severe sepsis/shock | 8.5 (0–22) | 13 (1–31) | 6.5 (0–19) | 9 (3–14) | 29 (22–36) | NS |
| IL- 8 | ||||||
| No sepsis | 10 (4–18) | 10 (5–22) | 16 (12–35) | 16.5 (10–23) | 2 (0–4) | .006 |
| Sepsis | 7 (2–15) | 7 (3–18) | 10 (4–34) | 11 (5–19) | 5 (3–16) | NS |
| Severe sepsis/shock | 6 (2–19) | 5 (2–16) | 14 (5–61) | 13 (1–27) | 24 (9–39) | NS |