Table 5.
Biomarkers and Cytokines According to Hypoxemia and MV
| Biomarkers | NE | GPC | GNB | ATP | VIR | P Value |
|---|---|---|---|---|---|---|
| CRP | ||||||
| Hypoxemia | ||||||
| Yes | 16 (8.2–27.8) | 21.3 (10.8–28.9) | 21.3 (8.8–31.8) | 19 (19–19) | 14 (8.9–21.6) | NS |
| No | 11.7 (6.4–19.8) | 18.8 (9.2–27.3) | 17.3 (11.3–24.4) | 10.7 (7.5–24.5) | 10.5 (0.8–16.8) | .002 |
| MV | ||||||
| Yes | 15.8 (8.4–27) | 17.6 (4.9–39.9) | 26.5 (11–34.2) | … | … | NS |
| No | 13.7 (6.9–21.8) | 19.9 (10.2–28.3) | 17.8 (10.2–28) | 11.3 (7.5–24.3) | 12 (8.9–16.8) | .001 |
| PCT | ||||||
| Hypoxemia | ||||||
| Yes | 0.5 (0.2–2.7) | 1.8 (0.4–7.4) | 0.6 (0.4–3.6) | 0.4 (0.4–0.4) | 0.3 (0.2–2.2) | NS |
| No | 0.3 (0.1–0.9) | 1.6 (0.5–6.5) | 0.6 (0.3–2.8) | 0.2 (0.1–0.4) | 0.2 (0.1–0.5) | < .00001 |
| MV | ||||||
| Yes | 2.3 (0.8–7) | 1.2 (0.3–12.9) | 6.6 (0.9–38.1) | … | … | NS |
| No | 0.4 (0.1–1.4) | 1.7 (0.5–7.1) | 0.5 (0.3–2.3) | 0.2 (0.1–0.4) | 0.2 (0.2–0.5) | < .00001 |
| TNF-α | ||||||
| Hypoxemia | ||||||
| Yes | 27 (16–44) | 28.5 (15–45) | 37 (16.5–71) | 23 (23–23) | 27 (10–31) | NS |
| No | 25 (14–40) | 28 (19–48.5) | 26 (13–52) | 27.5 (21–39.5) | 13.5 (8–22) | NS |
| MV | ||||||
| Yes | 29 (16–33) | 44 (17–48) | 27 (6–166) | … | … | NS |
| No | 25 (15–41) | 28 (16–47) | 33 (15.5–56.5) | 25 (21–39) | 14 (10–27) | NS |
| IL-1 | ||||||
| Hypoxemia | ||||||
| Yes | 16 (3–36) | 16 (3–35) | 13.5 (4–35.5) | 31 (31–31) | 14 (13–18) | NS |
| No | 14 (3–29.5) | 14.5 (4–28) | 21.5 (6.5–38) | 23 (4.5–35) | 5.5 (2–14) | NS |
| MV | ||||||
| Yes | 7 (0–15) | 5 (0–16) | 36 (13–93) | … | … | NS |
| No | 15 (3–33) | 15 (4–30) | 18 (4–29) | 24 (5–35) | 13 (4–14) | NS |
| IL-6 | ||||||
| Hypoxemia | ||||||
| Yes | 95 (23–246) | 133.5 (42–284) | 197 (69.5–931.5) | 26 (26–26) | 66 (16–405) | NS |
| No | 65 (25.5–154.5) | 159.5 (59.5–302.5) | 72 (24.5–211.5) | 51 (24.5–92.5) | 61 (30–192) | .02 |
| MV | ||||||
| Yes | 34 (30–143) | 79 (71–644) | 380 (70–2.075) | … | … | NS |
| No | 72 (25–175) | 151 (47–284) | 105 (41–324) | 43 (26–87) | 66 (30–192) | .002 |
| IL-10 | ||||||
| Hypoxemia | ||||||
| Yes | 6 (0–18) | 10 (0–28) | 7 (2.5–17.5) | 10 (10–10) | 23 (22–36) | NS |
| No | 4 (0–12) | 5.5 (0–18.5) | 5 (0–9.5) | 4 (0.5–14.5) | 9.5 (1–27) | NS |
| MV | ||||||
| Yes | 25 (5–59) | 13 (1–35) | 20 (0–273) | … | … | NS |
| No | 5 (0–14) | 6 (0–21) | 6 (0–12) | 5 (1–14) | 22 (1–27) | NS |
| IL- 8 | ||||||
| Hypoxemia | ||||||
| Yes | 8 (2–18) | 6.5 (2–18) | 19.5 (11–70) | 12 (12–12) | 9 (0–39) | .005 |
| No | 9 (3–17) | 6.5 (4–19) | 11 (4.5–24) | 14 (5–23.5) | 4 (3–5) | NS |
| MV | ||||||
| Yes | 13.5 (2–49) | 10 (6–86) | 64 (0–70) | … | … | NS |
| No | 8 (2–17) | 6 (2–18) | 13 (6–34) | 13 (5–23) | 4 (3–9) | .007 |