Table 7.
Effect of Antibiotic Treatment on Cytokines and Biologic Markers
| Prior Antibiotic Treatment |
||||||
|---|---|---|---|---|---|---|
| No |
Yes |
|||||
| Causal Diagnosis |
Causal Diagnosis |
|||||
| Biomarkers | No (n = 256) | Yes (n = 196) | P Value | No (n = 134) | Yes (n = 99) | P Value |
| CRP, mg/dL | 13.5 (7–21.6) | 19.1 (10–28.3) | < .0001 | 15.3 (6.4–22,7) | 17 (8.7–26) | NS |
| PCT, ng/mL | 0.41 (0.16–1.86) | 1.11 (0.3–5.28) | < .0001 | 0.32 (0.14–0.9) | 0.54 (0.2–2.28) | .017 |
| TNF-α, pg/mL | 26 (16–40) | 29 (15–49) | NS | 23 (15–44) | 24 (14–44) | NS |
| IL-1, pg/mL | 16 (3–34) | 15 (4–30) | NS | 13.5 (4–31) | 19 (3–35) | NS |
| IL-6, pg/mL | 81 (25–197) | 122 (43–352) | < .001 | 60 (24–149) | 79 (29–235) | .036 |
| IL-10, pg/mL | 6 (0–19) | 8 (0–23) | NS | 3 (0–9) | 3 (0–13) | NS |
| IL-8, pg/mL | 7 (2–16) | 6.5 (2–21) | NS | 10 (5–19) | 12 (5–24) | NS |
Data are presented as median (interquartile range). See Table 2 legend for expansion of abbreviations.