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Superimposition of EV71 3Cpro and HRV 3Cpro–AG7088 structures. Ribbon model of EV71 3Cpro structure (deep teal) is superimposed onto the ribbon model of HRV 3Cpro–AG7088 co-structure (PDB code: 1CQQ). HRV 3Cpro is colored gray, and AG7088 is colored by elements (carbon atoms in orange). The substrate binding pockets, S1′–S4, are indicated. The opened β-ribbon of EV71 3Cpro and the closed β-ribbon of HRV 3Cpro are indicated.
