Table 1.
Detection of SARS-CoV and apoptosis in tissue from infected civets
| Group (virus isolate) | Days post-infection | Tissue examined |
|||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lung |
Heart |
Cerebrum |
Small intestine |
||||||||||||||
| A | B | C | D | A | B | C | D | A | B | C | D | A | B | C | D | ||
| A (GZ01) | 3 | + | + | + | ND | − | − | − | − | ND | ND | + | + | ND | ND | + | ND |
| 13 | − | − | − | ND | − | + | − | − | ND | ND | + | − | ND | ND | − | ND | |
| 23 | − | − | − | ND | − | − | − | − | ND | ND | − | − | ND | ND | − | ND | |
| 34 | − | − | − | ND | − | − | − | − | ND | ND | − | − | ND | ND | − | ND | |
| 35 | − | − | − | ND | − | − | − | − | ND | ND | − | − | ND | ND | − | ND | |
| B (BJ01) | 3 | + | + | + | ND | + | + | − | − | ND | ND | + | + | ND | ND | + | ND |
| 13 | − | − | − | ND | − | − | − | − | ND | ND | + | − | ND | ND | − | ND | |
| 23 | − | − | − | ND | − | − | − | − | ND | ND | − | − | ND | ND | − | ND | |
| 34 | − | − | − | ND | − | − | − | − | ND | ND | − | − | ND | ND | − | ND | |
| 35 | − | − | − | ND | − | − | − | − | ND | ND | − | − | ND | ND | − | ND | |
A, virus isolation; B, RT-PCR; C, ISH; D, apoptosis; (+), positive for virus isolation, PCR, ISH and apoptosis; (−), negative for virus isolation, PCR, ISH and apoptosis; ND, not determined.