Table 1.

In vitro activity on T. cruzi (Dm28c strain or Tulahuen 2 epimastigotes) of the [V^IVO(SO₄)(H₂O)₂(NN)] and [V^IVO(L-2H)(NN)] complexes [117], [118], [277], [278], [279], [280].

Compound	IC50 ± SD (μM)	Compound	IC50 ± SD (μM)
[VIVO(SO4)(H2O)2(dppz)]	ca. 3	[VIVO(L1-2H)(phen)]	2.0
[VIVO(SO4)(H2O)2(tdzp)]	15.6 ± 4.88	[VIVO(L2-2H)(phen)]	3.1
[VIVO(SO4)(H2O)2(phendione)]	7.24 ± 5.27	[VIVO(L3-2H)(phen)]	2.3
[VIVO(SO4)(H2O)2(epoxyphen)]	21.91 ± 9.94	[VIVO(L4-2H)(phen)]	1.6
		[VIVO(L5-2H)(phen)]	3.8
[VIVO(L1-2H)(bipy)]	73	[VIVO(L1-2H)(aminophen)]	0.50 ± 0.02
[VIVO(L2-2H)(bipy)]	84	[VIVO(L2-2H)(aminophen)]	0.27 ± 0.09
[VIVO(L3-2H)(bipy)]	76.2 ± 9.7	[VIVO(L3-2H)(aminophen)]	0.52 ± 0.02
[VIVO(L4-2H)(bipy)]	161 ± 57	[VIVO(L4-2H)(aminophen)]	0.51 ± 0.02
[VIVO(L5-2H)(bipy)]	58.0 ± 14.8	[VIVO(L5-2H)(aminophen)]	0.51 ± 0.02
[VIVO(L1-2H)(dppz)]	13	[VIVO(L1-2H)(epoxyphen)]	1.0 ± 0.1
[VIVO(L2-2H)(dppz)]	19	[VIVO(L2-2H)(epoxyphen)]	0.9 ± 0.2
[VIVO(L3-2H)(dppz)]	4.70 ± 3.35	[VIVO(L3-2H)(epoxyphen)]	1.2 ± 0.3
[VIVO(L4-2H)(dppz)]	12.7 ± 8.27	[VIVO(L4-2H)(epoxyphen)]	3.9 ± 0.6
[VIVO(L5-2H)(dppz)]	5.05 ± 1.60	[VIVO(L5-2H)(epoxyphen)]	1.1 ± 0.3

IC₅₀, concentration required for inhibition of 50% of culture growth.