Fig. 1.

Schematic representation of HIV-1 gp41 (A) and APP (B). TM domain and membranotropic sequences in each protein are depicted darker. TM and juxtamembrane regions are enlarged and for APP the sequence involved in processing is shown with the major sites of cleavage by α-, β-, and γ-secretases highlighted. Dashed arrows indicate APP intramembrane cleavage sites. The CRAC motifs are underlined. TM glycines and alanine residues involved in GxxxG/A motifs are shown in bold. Locations of gp41 inhibitor peptides and Aβ 40/42 peptides are depicted with dark lines. Numbering refers to HIV gp160 precursor, BH10 isolate (A) and human APP770 isoform (B). See text for details.