Table 1.
Distribution of Uncorrected Urinary Phthalate Metabolite Concentrations (ng/mL) in the PROGRESS cohort by Trimester
| Second Trimester (N=948) | Third Trimester (N=792) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parent Class | Parent | Metabolite | 25% | 50% | 75% | 90% | Detection Rate | 25% | 50% | 75% | 90% | Detection Rate |
| High Molecular Weight | DEHP | MEHP | 2.7 | 5.7 | 10.7 | 17.1 | 96% | 2.8 | 5.4 | 9.6 | 18.3 | 96% |
| MEOHP | 9.4 | 17.3 | 34.4 | 55.6 | 100% | 12.3 | 21.3 | 37.1 | 59.4 | 100% | ||
| MEHHP | 10.4 | 18.5 | 37.7 | 61.2 | 100% | 12.3 | 21.2 | 38.8 | 64.9 | 100% | ||
| MECPP | 22.0 | 40.2 | 73.2 | 115.0 | 100% | 26.8 | 44.3 | 76.1 | 127.0 | 100% | ||
| DEHTP | MECPTP | 0.9 | 1.7 | 3.2 | 6.2 | 98% | 1.1 | 2.1 | 3.7 | 7.6 | 98% | |
| DiNP | MONP | 0.6 | 1.2 | 2.4 | 4.6 | 85% | 0.8 | 1.5 | 2.6 | 4.9 | 93% | |
| MCOP | 2.3 | 4.4 | 7.7 | 13.3 | 100% | 2.5 | 4.1 | 7.0 | 12.5 | 100% | ||
| DiDP | MCNP | 0.6 | 0.9 | 1.5 | 2.2 | 97% | 0.6 | 0.9 | 1.5 | 2.2 | 98% | |
| DOP | MCPP* | 0.8 | 1.4 | 2.4 | 3.9 | 92% | 0.9 | 1.5 | 2.4 | 3.7 | 94% | |
| BBzP | MBzP | 2.5 | 5.0 | 10.4 | 21.6 | 99% | 2.6 | 5.6 | 10.9 | 19.1 | 99% | |
| Low Molecular Weight | DiBP | MHiBP | 1.8 | 3.4 | 6.2 | 10.2 | 99% | 1.9 | 3.5 | 6.1 | 10.7 | 99% |
| MiBP | 4.6 | 8.9 | 16.1 | 25.4 | 99% | 5.1 | 9.5 | 16.8 | 29.5 | 99% | ||
| DBP | MBP** | 38.0 | 79.4 | 150.3 | 255.0 | 100% | 42.9 | 80.4 | 148.3 | 267.7 | 100% | |
| MHBP | 3.4 | 6.9 | 13.3 | 24.5 | 99% | 3.8 | 7.5 | 14.0 | 25.4 | 99% | ||
| DEP | MEP | 52.2 | 119.0 | 296.3 | 771.2 | 100% | 53.9 | 123.5 | 354.5 | 997.0 | 100% | |
| Phthalate Alternatives | DINCH | MCOCH | <LOD | <LOD | <LOD | <LOD | 2% | <LOD | <LOD | <LOD | <LOD | 3% |
| MHiNCH | <LOD | <LOD | <LOD | <LOD | 4% | <LOD | <LOD | <LOD | <LOD | 8% | ||
*
Also a minor metabolite of several high molecular weight phthalates
**
Also a minor metabolite of BBzP
<LOD: Below the limit of detection. LODs were 0.5 ng/mL (MCOCH) and 0.4 ng/mL (MHiNCH)