Table 3.
Metabolites of High Molecular Weight Phthalates | Metabolites of Low Molecular Weight Phthalates | ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DEHP | DEHTP | DiNP | DiDP | DOP | BBzP | DiBP | DBP | DEP | |||||||
MEHP | MEOHP | MEHHP | MECPP | MECPTP | MONP | MCOP | MCNP | MCPP | MBzP | MHiBP | MiBP | MBP | MHBP | MEP | |
CR (95% CI) | CR (95% CI) | CR (95% CI) | CR (95% CI) | CR (95% CI) | CR (95% CI) | CR (95% CI) | CR (95% CI) | CR (95% CI) | CR (95% CI) | CR (95% CI) | CR (95% CI) | CR (95% CI) | CR (95% CI) | CR (95% CI) | |
Age (Second Trimester) | |||||||||||||||
<25 | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref |
25–35 | 1.08 (0.94, 1.25) | 0.98 (0.86, 1.12) | 1.02 (0.89, 1.16) | 1.00 (0.88, 1.12) | 0.90 (0.78, 1.04) | 0.97 (0.84, 1.12) | 0.99 (0.87, 1.13) | 0.96 (0.86, 1.07) | 0.98 (0.87, 1.10) | 0.90 (0.76, 1.06) | 1.00 (0.88, 1.14) | 1.02 (0.90, 1.16) | 1.06 (0.92, 1.22) | 1.05 (0.90, 1.22) | 1.13 (0.94, 1.36) |
>35 | 1.00 (0.81, 1.25) | 0.91 (0.74, 1.11) | 0.97 (0.79, 1.19) | 0.95 (0.79, 1.14) | 0.83 (0.66, 1.03) | 0.98 (0.78, 1.22) | 1.01 (0.83, 1.23) | 0.95 (0.80, 1.12) | 1.03 (0.86, 1.25) | 0.66 (0.51, 0.85) | 0.99 (0.81, 1.21) | 1.05 (0.86, 1.27) | 1.19 (0.96, 1.48) | 1.14 (0.90, 1.44) | 1.06 (0.79, 1.40) |
BMI (second trimester) | |||||||||||||||
<25 | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref |
25–30 | 0.92 (0.79, 1.07) | 0.95 (0.82, 1.08) | 0.97 (0.84, 1.12) | 0.97 (0.85, 1.09) | 0.90 (0.78, 1.05) | 0.98 (0.84, 1.14) | 0.95 (0.83, 1.09) | 0.92 (0.82, 1.03) | 0.93 (0.82, 1.05) | 0.86 (0.72, 1.02) | 0.98 (0.85, 1.12) | 0.99 (0.86, 1.13) | 0.93 (0.81, 1.08) | 0.91 (0.78, 1.07) | 1.19 (0.98, 1.44) |
>30 | 0.94 (0.79, 1.12) | 1.00 (0.85, 1.18) | 1.05 (0.89, 1.24) | 1.07 (0.93, 1.25) | 0.96 (0.81, 1.15) | 1.11 (0.93, 1.32) | 1.14 (0.97, 1.33) | 1.06 (0.93, 1.21) | 0.99 (0.85, 1.15) | 0.90 (0.73, 1.1) | 1.04 (0.89, 1.22) | 1.16 (0.99, 1.36) | 1.05 (0.88, 1.24) | 0.94 (0.78, 1.13) | 1.15 (0.92, 1.44) |
Socioeconomic Status | |||||||||||||||
1 (lowest) | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref |
2 | 1.23 (0.97, 1.56) | 1.15 (0.92, 1.43) | 1.16 (0.93, 1.46) | 1.16 (0.95, 1.42) | 1.08 (0.85, 1.37) | 1.28 (1.01, 1.63) | 1.26 (1.02, 1.56) | 1.13 (0.94, 1.35) | 1.12 (0.91, 1.37) | 1.31 (0.99, 1.73) | 1.14 (0.92, 1.42) | 1.12 (0.9, 1.38) | 1.31 (1.03, 1.66) | 1.31 (1.01, 1.68) | 1.34 (0.99, 1.83) |
3 | 1.24 (0.96, 1.60) | 1.02 (0.80, 1.29) | 1.05 (0.82, 1.33) | 1.01 (0.82, 1.26) | 0.98 (0.75, 1.27) | 1.12 (0.86, 1.45) | 1.10 (0.87, 1.38) | 0.99 (0.82, 1.21) | 1.10 (0.88, 1.36) | 1.22 (0.91, 1.65) | 1.09 (0.86, 1.37) | 1.04 (0.82, 1.30) | 1.28 (1.00, 1.65) | 1.33 (1.01, 1.74) | 1.42 (1.02, 1.97) |
4 | 1.16 (0.88, 1.53) | 1.02 (0.79, 1.32) | 1.07 (0.82, 1.39) | 0.99 (0.78, 1.25) | 0.87 (0.66, 1.15) | 1.27 (0.96, 1.68) | 1.20 (0.94, 1.54) | 1.04 (0.85, 1.29) | 1.08 (0.86, 1.37) | 1.18 (0.86, 1.64) | 1.12 (0.87, 1.44) | 1.06 (0.83, 1.36) | 1.32 (1.01, 1.73) | 1.35 (1.01, 1.81) | 1.53 (1.07, 2.18) |
5–6 (highest) | 1.37 (1.02, 1.83) | 1.10 (0.84, 1.44) | 1.10 (0.84, 1.45) | 1.03 (0.80, 1.32) | 0.86 (0.64, 1.16) | 1.22 (0.91, 1.65) | 1.04 (0.80, 1.36) | 1.03 (0.82, 1.28) | 1.13 (0.88, 1.44) | 1.24 (0.88, 1.75) | 1.25 (0.96, 1.62) | 1.22 (0.94, 1.59) | 1.43 (1.07, 1.90) | 1.46 (1.07, 1.99) | 1.57 (1.08, 2.29) |
Education | |||||||||||||||
< High School | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref |
High School | 1.08 (0.93, 1.25) | 1.07 (0.93, 1.23) | 1.06 (0.92, 1.22) | 1.04 (0.92, 1.18) | 1.01 (0.87, 1.18) | 1.02 (0.87, 1.18) | 1.01 (0.88, 1.15) | 1.03 (0.92, 1.16) | 1.08 (0.95, 1.23) | 1.20 (1.01, 1.43) | 1.08 (0.94, 1.23) | 1.05 (0.91, 1.20) | 1.08 (0.93, 1.25) | 1.16 (0.99, 1.35) | 1.16 (0.95, 1.41) |
>High School | 1.01 (0.85, 1.19) | 0.90 (0.77, 1.05) | 0.91 (0.78, 1.07) | 0.86 (0.75, 0.99) | 0.74 (0.63, 0.88) | 0.92 (0.78, 1.09) | 0.91 (0.78, 1.06) | 1.00 (0.88, 1.13) | 0.97 (0.84, 1.12) | 0.83 (0.68, 1.01) | 0.96 (0.83, 1.12) | 0.95 (0.82, 1.11) | 1.02 (0.87, 1.21) | 1.07 (0.89, 1.28) | 1.13 (0.91, 1.40) |
First Pregnancy | |||||||||||||||
Yes | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref |
No | 1.09 (0.95, 1.25) | 1.02 (0.90, 1.15) | 1.05 (0.92, 1.19) | 1.03 (0.92, 1.16) | 1.22 (1.06, 1.39) | 1.02 (0.89, 1.17) | 1.05 (0.93, 1.19) | 0.96 (0.86, 1.06) | 0.97 (0.86, 1.09) | 1.04 (0.88, 1.21) | 1.08 (0.96, 1.22) | 1.15 (1.02, 1.30) | 1.06 (0.92, 1.21) | 0.97 (0.84, 1.11) | 0.89 (0.75, 1.06) |