Fig. 2.

A) The sequence of αS. The N-terminal region is shown in green, the NAC region is shown in black and the C-terminal region is shown in blue. B) Final form adopted by αS monomers in amyloid fibrils as proposed by Vialr et al. [5] More recent cryo-EM studies of the protofilament stage of αS amymloidogenesis suggest that αS forms polymorphic structures that may have more than 5 β-strands. The strands β1 and β2 of αS have been underlined in A) and highlighted in B) because of the growing interest in this region as a possible pre-amyloid secondary structure formed by αS on the path to amyloid fibril formation. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)