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. Author manuscript; available in PMC: 2020 May 20.
Published in final edited form as: Nature. 2019 Nov 20;575(7784):699–703. doi: 10.1038/s41586-019-1763-5

Extended Data Figure 6 |. ecDNA is highly accessible in early interphase chromatin.

Extended Data Figure 6 |

a, The workflow to evaluate the accessibility of ecDNA in interphase cells.

b, Representative images of FISH, ATAC-see and MitoTracker Deep Red FM signal colocalization in COLO320DM cells.

c, Pearson correlation of FISH signal pixel intensity and ATAC-see signal pixel intensity in 4 representative single cells. At least 27,000 pixels for each cell were analyzed.