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. Author manuscript; available in PMC: 2023 Sep 6.
Published in final edited form as: Chem Rev. 2019 Dec 5;120(6):3210–3229. doi: 10.1021/acs.chemrev.9b00472

Figure 10.

Figure 10.

(A) Overlay of X-ray structures of HER2 bound to Pertuzumab Fab (PDB 1S78) and Trastuzumab Fab (PDB ID 1N8Z). HER2 is a dimer, but one of the subunits is colored gray and shown uncomplexed with Fab for clarity. B-Vaxx components are modeled after regions 266–296 (magenta spheres) and 597–626 (black spheres). (B) B-Vaxx peptide epitopes.