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. Author manuscript; available in PMC: 2023 Sep 6.
Published in final edited form as: Chem Rev. 2019 Dec 5;120(6):3210–3229. doi: 10.1021/acs.chemrev.9b00472

Figure 3.

Figure 3.

Computational design of an immunogen (FFL_001) for RSV. The scaffolded epitope from RSV F protein, shown in blue, was templated on the RSV antibody motavizumab. FFL_001 elicited antibodies in non-human primates (e.g., 17-HD9) that bound the epitope in a conformationally identical manner but not with the same angle of approach.