Table 3.
Risk cut-off percentile*) | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) |
---|---|---|---|---|
≥ 99th | 6.5 | 99.4 | 23.7 | 97.2 |
≥ 95th | 22.5 | 96.4 | 15.7 | 97.6 |
≥ 90th | 36.2 | 91.6 | 11.5 | 97.9 |
≥ 85th | 47.1 | 87.2 | 10.0 | 98.2 |
≥ 80th | 59.4 | 82.9 | 9.5 | 98.5 |
≥ 75th | 65.9 | 78.0 | 8.3 | 98.7 |
≥ 70th | 72.5 | 72.9 | 7.5 | 98.9 |
≥ 65th | 79.0 | 67.5 | 6.8 | 99.1 |
≥ 60th | 83.3 | 62.6 | 6.3 | 99.2 |
≥ 55th | 87.7 | 56.9 | 5.8 | 99.4 |
≥ 50th | 91.3 | 51.9 | 5.4 | 99.5 |
NPV, negative predictive value; PPV, positive predictive value
Percentile of the predicted risk distribution observed in the training sample. Performance characteristics are then shown in the test sample when using the given risk cut-off for classifying as unrecognized dementia. Values for the model that considered the full set of predictors are included in Supplementary Table S3.