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. 2020 Mar 25;15(3):e0230450. doi: 10.1371/journal.pone.0230450

Fig 2. Up-regulated miR 122 inhibited hepatocellular carcinoma cells proliferation through regulating ADAM17.

Fig 2

(A) MTT assay of HepG2 cells transfected with miR-122 mimic for 24 h in vitro. (B) HNF-4α, ADAM17, EGFR, AKT, p-AKT, F-Caspase 3 and C-Caspase 3 protein expression in HepG2 cells transfected with miR-122 mimic at 200 nM. Relative quantification of western blot results ADAM17 (C), EGFR (D), p-AKT/AKT (E), and cleaved caspase 3/caspase 3 (F) levels expressed relative to control. (*P < 0.05 vs. the control). CON: control; NC: negative control.