Fig 7. Proposed model of chromatin remodeler’s recycling during gene activation.

In this model, both unacetylated Ino80p and Snf2p bind to the INO1 promoter before induction. Once INO1 is induced, histone acetylases Gcn5p and Esa1p acetylate chromatin remodelers Snf2p and Ino80p, allowing the remodelers to dissociate from the INO1 promoter. Once freed from the INO1 promoter region, the remodelers can be recruited to the CUP1 promoter and activate CUP1 expression.