Table 1. Evaluation of OS by baseline AFP and TGF-β1 (Parts A and B combined).
| Baseline biomarker status | n | Median OS | 95% CI | p-value1 |
|---|---|---|---|---|
| Baseline AFP | ||||
| >400 ng/mL | 66 | 5.6 mo | 3.4–8.9 | |
| ≤400 ng/mL | 81 | 13.0 mo | 10.5–16.6 | 0.0003 |
| Baseline TGF-β12 | ||||
| >median | 74 | 5.4 mo | 3.1–10.8 | |
| ≤median | 74 | 12.1 mo | 8.9–15.5 | 0.022 |
1p-value for difference between baseline biomarker status groups.
2Median baseline TGF-β1 was 3.52 ng/mL.
AFP = alpha fetoprotein; mo = months; OS = overall survival; TGF-β1 = transforming growth factor beta 1.