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. Author manuscript; available in PMC: 2020 Mar 25.
Published in final edited form as: Biomaterials. 2019 Jan 21;197:296–304. doi: 10.1016/j.biomaterials.2019.01.027

Fig. 1. Schematic representation of the bone mimetic environment of metastasis.

Fig. 1.

A. Human mesenchymal stem cells (hMSCs) were seeded on a miniaturized medical grade, calcium phosphate polycaprolactone scaffold (mPCL-CaP) and maintained in osteogenic medium for 30 days that engendered osteogenic maturation. B. PCa cells were seeded on the bone mimetic environment (BME) as tumoroids and monitored over time by live-cell fluorescence microscopy. C. Established tumoroids were subjected to chemo- or radiation therapy and longitudinally monitored for therapeutic response by live-cell fluorescence microscopy.