Table 4.
Physiological and ventilation variables at baseline and after 2, 4, 12, 24, and 48 h (changes from baseline): median (25th/75th percentiles) or mean ±SD (RR ventilatory/respiratory rate, OI oxygenation index, CVP central venous pressure)
| Surfactant | Controls | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Baseline | 2 h | 4 h | 12 h | 24 h | 48 h | Baseline | 2 h | 4 h | 12 h | 24 h | 48 h | |
| Oxygen. index PaO2/FIO2 | 71.3 | +54 (16/90) | +57 (19/92) | +39 (19/72) | +24 (3/106) | +38 0/122) | 64.3 | +9 (0/25)* | +20 (1/50) | +20 (0/47) | +42 (0/98) | +22 (0/78) |
| Hallman OI (cmH2O/mmHg) | −10 (−17/−7) | −11 (−16/−7) | −12 (−15/−4) | −7 (−19/−2) | −9 (−18/−3) | −2 (−7/1) | −4 (−9/0) | −4 (−12/0) | −6 (−12/−2) | −5 (12/−2) | ||
| PaO2 (mmHg) | +14 (7/38) | +10 (0/37) | +9 (−5/22) | +5 (−1/9) | +5 (−4/25) | +4 (−2/11)* | +3 (−2/25) | +6 (−4/19) | +6 (−2/33) | +6 (−2/19) | ||
| paCO2 (mmHg) | −4 (−9/5) | −4 (−7/9) | +2 (−7/14) | +7 (−1/14) | +2 (−8/13) | −3 (−12/4) | −4 (−12/8) | −5 (−12/6) | −4 (−12/2) | −1 (−10/5) | ||
| RR (1/min) | 0.0 (−5/0) | −1.5 (−4.5/0) | −3 (−4/0) | −3 (−12/0) | −2.8 (−9/0.5 | 0 (0/0) | 0 (0/0) | 0 (0/3) | 0 (−2/3) | 0 (−1/4) | ||
| PIP (cmH2O) | −1 (−3/1) | −2 (−4/0) | −2 (−4/−1) | −3 (−6/0) | −5 (−7/−1) | 0 (−1/0) | 0 (−2/0) | −1 (−2/1) | −1 (−3/0) | −1 (−3/0) | ||
| PEEP (cmH2O) | 0.0 (−0.9/0) | 0.0 (−0.9/0) | 0.0 (−1/0) | 0.0 (−1.6/0) | −0.5 (−2/0) | 0.0 (0/0) | 0.0 (0/0) | 0.0 (−2/1) | 0.0 (−1/1) | 0.0 (−1/1) | ||
| Mean airway pressure (cmH2O) | −1 (−1.7/0) | −1 (−2.7/0.1) | −1 (−3.2/0.5) | −1.5 (−5/−0.9 | −1 (−6/1.3) | 0.4 (0/1.5)* | 0.4 (−2/2) | 0.4 (−2/2) | 0.0 (−2/2)* | 0.0 (−2/1.5) | ||
| Ventilatory index (RR×PIP×pCO2/1000) | −7 (−12/−1) | −5 (−11/1) | −3 (−12/5) | −5 (−15/5) | −5 (−16/5) | −9 (−18/−1) | −10 (−22/1) | −10 (−25/5) | −10 (−24/3) | −6 (−19/6) | ||
| BP systolic (mmHg) | 109±19 | 109±13 | 108±31 | 109±19 | 104±24 | 105±16 | 97±13 | 100±21 | 102±24 | 112±14 | 112±26 | 110±18 |
| BP diastolic (mmHg) | 56±18 | 61±13 | 55±12 | 60±13 | 58±16 | 57±12 | 51±9 | 52±11 | 51±12 | 60±11 | 58±12 | 56±11 |
| CVP (mmHg) | 11±5 | 11±5 | 11±5 | 10±5 | 10±4 | 9±5 | 13±6 | 11±5 | 12±5 | 11±6 | 11±5 | 12±7 |
| Heart rate (1/min) | 143±29 | 134±32 | 136±31 | 133±27 | 134±22 | 117±34 | 138±28 | 139±26 | 133±24 | 139±24 | 130±22 | 130±22 |
| Hemoglobin (g/dl) | 11.9±2.3 | 12.4±2.4 | 12.0±2.0 | 12.2±1.6 | 13.1±2.1 | 13.5±1.8 | 11.1±1.8 | 11.0±1.7 | 11.3±1.6 | 12.5±1.9 | 12.2±2.1 | 11.7±1.8 |