Table 6.
p values in linear models for the change from baseline in the PaO2/FIO2 ratio between 2 and 48 h including various additional factors of clinical concern. The significant interactions between treatment and morbidity characteristics (e.g., pneumonia, PaO2/FIO2<65) indicate that the difference between treatment groups depends on the baseline value of the oxygenation index and on the presence of pneumonia as a causative diagnosis for ARDS. These differences are clearly demonstrated by the median profiles which are displayed separated for the respective subgroups
| Factor of interest | Surfactant treatment | Factor of interest (morbidity characteristics) | Treatment by factor |
|---|---|---|---|
| No | 0.079 | − | – |
| Baseline PaO2/FIO2 (<65 vs. >65) | 0.220 | 0.019 | 0.028 |
| Baseline lung injury score (<3.1 vs. >3.1) | 0.103 | 0.958. | 0.426 |
| Baseline PRISM III (<12 vs. >12) | 0.069 | 0.232 | 0.786 |
| Age (<1 vs. ≥2 years) | 0.076 | 0.291 | 0.783 |
| Sex | 0.139 | 0.727 | 0.285 |
| Body weight (≤12 vs. >12 kg) | 0.059 | 0.570 | 0.055 |
| Time since FIO2 >0.5 before randomization (<24 vs. >24 h) | 0.122 | 0.617 | 01.77 |
| Time since PIP >30 cmH2O before randomization (<30 vs. >30 h) | 0.096 | 0.269 | 0.893 |
| Pneumonia (primary pulmonary ARDS) | 0.001 | 0.047 | 0.002 |
| Sepsis | 0.123 | 0.085 | 0.965 |
| Under immunosuppression | 0.135 | 0.135 | 0.743 |