Table 3.
Ventilatory parameters during the first 15 days of MV, median [interquartile range (IQR)]
| Day 1 | Day 3 | Day 7 | Day 15 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Survivors n = 80 | Non-survivors n = 56 | p Value | Survivors n = 75 | Non-survivors n = 43 | p Value | Survivors n = 58 | Non-survivors n = 28 | p Value | Survivors n = 31 | Non-survivors n = 11 | p Value | |
| Peak inspiratory pressure (cm H2O) | 32 (25–35.2) | 33 (28–39.2) | 0.10 | 30 (25–33) | 34 (27.5–41) | <0.01 | 28.5 (25–34.5) | 38.5 (33.7–45) | <0.01 | 26 (22.2–30.5) | 35 (16.5–41) | 0.29 |
| Plateau pressure (cm H2O) | 29 (23–32) | 32 (28–36) | <0.01 | 25 (22–30) | 32 (28–37.7) | <0.01 | 26 (20.7–30) | 32.5 (28.2–39.7) | <0.01 | 24 (20.2–27.7) | 32.5 (18.7–38.2) | 0.23 |
| Mean airway pressure (cm H2O) | 12 (9.7–15) | 20 (14.5–22) | <0.01 | 12.5 (10–14) | 20 (15–23) | <0.01 | 12 (10–15) | 21 (19–23) | <0.01 | 13 (10–15) | 19.5 (15.7–21.5) | 0.06 |
| Applied positive end expiratory pressure (cm H2O) | 7 (5–10) | 10 (7–12) | <0.01 | 7 (5–10) | 12 (8.5–13) | <0.01 | 8.5 (5–10) | 13 (8.7–15) | <0.01 | 7.5 (5–9.7) | 14 (11.5–15) | <0.01 |
| PaO2 to FiO2 | 121.5 (101–169) | 80.5 (63–122) | <0.01 | 150 (100–202) | 85 (57–114) | <0.01 | 144 (118–181) | 85 (52–120) | <0.01 | 164 (130–220) | 60 (50–118) | <0.01 |
| Oxygenation index | 9 (7–13) | 27 (16–35) | <0.01 | 9 (5.5–11) | 25 (12–41) | <0.01 | 8 (5–15) | 25 (11–43) | <0.01 | 5 (4–12) | 38 (32–40) | 0.01 |
| pH | 7.33 (7.25–7.40) | 7.27 (7.20–7.38) | 0.15 | 7.37 (7.30–7.41) | 7.27 (7.22–7.40) | 0.10 | 7.40 (7.36–7.42) | 7.35 (7.32–7.38) | 0.10 | 7.40 (7.33–7.44) | 7.28 (7.26–7.39) | 0.05 |
| PCO2 (mmHg) | 48 (42–62) | 57 (38–74) | 0.45 | 50 (41–65) | 55 (43–66) | 0.57 | 58 (50–62) | 58 (45–64) | 0.95 | 50 (44–0.56) | 76 (68–87) | 0.02 |