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. 2020 Mar 12;14(1):63–71. doi: 10.1007/s13206-020-4106-6

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© The Korean BioChip Society and Springer 2020

This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.

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(A) A schematic drawing of surface adsorption-based extracorporeal devices. The inner surface of fibers bundled in the device is functionalized with proteins or synthetic polymers, which are known to capture a wide range of pathogens and toxins in blood18. (B) An illustration showing a cross-sectional view of porous beads and their internal structures of the CytoSorb® filter, which was developed for lowering cytokine levels in blood of septic patients20. (C, D, E) Magnetic particle-assisted blood treatment approaches. (C) Magnetic particles are functionalized with pathogen-capturing moieties21. (D) Magnetic particles coated with anti-IL6 was developed for removing a proinflammatory cytokine in blood22. (E) An engineered human FcMBL molecule conjugated on magnetic nanoparticles where the FcMBL molecules were designed to be oriented with carbohydrate recognition domains facing outward23.