Table 6.

Pathogens and antibiotic agents not associated with de-escalation of antibiotic therapy, in a prospective cohort of 143 patients with ventilator-associated pneumonia

Pathogens not associated with de-escalation therapy	Antibiotics not de-escalated		Patients in whom treatment was not de-escalated, n
	Initial	Final
Bronchoalveolar lavage
P. aeruginosa	PT – Q	PT – Q	10
P. aeruginosa	M – Q	M – Q	11
Quantitative tracheal aspirate
MRSA – P. aeruginosa	L – PT – A	L – PT – A	11
MRSA – MSSA – P. aeruginosa	L – M – A	L – M – A	3
Klebsiella – Morganella	M – A	M – A	5
P. aeruginosa – Streptococcus	L – M – Q	L – M – Q	5
Serratia – Proteus	M – Q	M – Q	4
MRSA – P. aeruginosa – Serratia	L – PT – A	L – PT – A	1
Haemophilus – E. coli	M – Q	M – Q	9
MRSA – P. aeruginosa	L – PT – A	L – PT – A	4
MRSA – P. aeruginosa – Proteus	L – M – A	L – M – A	1
MRSA – MSSA	PT – A	PT – A	1
MRSA	L	L	5
Klebsiella – Haemophilus	L	L	2
Klebsiella	M – Q	M – Q	5
Serratia	M – Q	M – Q	6
Enterococcus	L	L	2

MSSA, methicillin-sensitive Staphyloccoccus aureus; MRSA, methicillin-resistant Staphylococcus aureus; L, linezolide; M, meropenem; A, amikacin; Q, quinolone; PT, piperacillin/tazobactam; CTZ, ceftazidime