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. 2004 Feb 22;10(3):290–293. doi: 10.1038/nm1001

Figure 1. Histological lesions and immunohistochemical and ultrastructural detection of SCV in lungs of experimentally infected macaques.

Figure 1

(a) DAD in pulmonary alveoli (control group). (b) Normal pulmonary alveoli (prophylactic group). (c,d) SCV antigen expression in type 1 pneumocytes (control group). (e) Lack of SCV antigen expression in pulmonary alveoli (prophylactic group). (f) Viral nucleocapsids in cytoplasmic vesicle of type 1 pneumocyte (control group), showing pinocytotic vesicles (arrowheads) and basement membrane (arrows). Scale bar, 1 μm. (g) Higher magnification of viral nucleocapsids shown in f. Scale bar, 200 nm. (h) SCV antigen expression in type 2 pneumocytes (control group). Sections were stained with H&E (a,b), for SCV antigen (c–e,h), or with uranyl acetate and lead citrate (f,g). Original magnification, ×25 (a left, b left), ×100 (a right, b right, c,e) or ×250 (d,h).