Figure 2.

Same-site ChR2 laser reverses distant Fos activation induced by NAc DNQX microinjections. Top, Sagittal brain maps show recruitment of limbic Fos elevations by DNQX microinjections in NAc shell compared with vehicle (left; red/orange). ChR2 laser induced reversals of DNQX-induced Fos is shown as suppressions from DNQX-alone levels (right; blue). Middle, Bar graphs depict the quantitative percentage increase of DNQX-induced Fos elevations in limbic structures over vehicle control levels; dashed line at 100% = vehicle levels (red/orange bars). Center uncolored bars show Laser + DNQX levels compared with vehicle levels. Bottom, Bars (blue) show suppression of Laser + DNQX levels compared with DNQX-alone levels. *p < 0.05, **p < 0.01, ***p < 0.001.