Figure 5.

Neural activity during seizure initiation and propagation. A, Baseline activity is extracted from a 4 min window before temperature elevation. The preictal period (at least 8 min immediately preceding the seizure in Scn1a+/− mice, or a temperature matched epoch in wild-type mice) is broken into two 4 min segments (early and late preictal). B, C, Raster plots of 30 s of neuronal activity of putative principal cells (black) and PV-INs (red) from an Scn1a+/− (B) and a wild-type mouse (C) during temperature elevation, that, in Scn1a+/− mice, leads to a seizure.