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. 2020 Mar 25;6(13):eaaz2129. doi: 10.1126/sciadv.aaz2129

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Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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Fig. 6 — (A) Count of metaphase spermatocytes (pHH3-positive) in seminiferous tubules from WT and Skp1^cKO testes. Scale bar, 25 μm. (B) Western blot (WB) analysis of cell cycle regulators in Skp1^cKO testes. (C) Skp1-deficient spermatocytes are incompetent for MI entry with OA induction. Scale bar, 10 μm. (D) Histone H1 kinase assay for the MPF activity in WT (control) and Skp1^cKO testes at 2 and 6 dpt. Immunoglobulin G (IgG) serves as a negative control. IP, immunoprecipitation. (E) Key functions of SKP1 during male meiosis. This diagram summarizes the major meiotic defects in Skp1^cKO testes. Note the accumulation of HORMAD1 on LEs in Y pachynema and its increased abundance on LEs in diplonema in the absence of SKP1. For illustration purpose, SKP1 and HORMAD1 are shown next to the LEs instead of overlaying.