Table II.
Serum metabolite concentrations in NCH and CH LE and SD rats.
| Metabolite | LE | P value | SD | P value | P value LE NCH vs. SD NCH | ||
|---|---|---|---|---|---|---|---|
| NCH | CH | NCH | CH | ||||
| Indole (μM) | .35±.07 | .34±.03 | .99 | .44±.08 | .52±.03 | .45 | .78 |
| Tryptophan (mM) | 98.2±4.3 | 112.3±5.8 | .06 | 116.2±17.7 | 143.9±23.5 | .43 | .91 |
| Serotonin (μM) | 2.8±.1 | 2.4±.1 | .06 | 4.8±.2 | 4.4±.5 | .50 | .02 |
| Kynurenine (μM) | .65±.03 | .58±.06 | .78 | 1.47±.18 | 2.00±.21 | .08 | .02 |
| Kynurenine/tryptophan ratio | 6.7±.5 | 5.1±.5 | .11 | 13.0±1.5 | 14.8±1.6 | .66 | .02 |
| Indole-3-propionic acid (μM) | 5.1±.6 | 4.8±.7 | .90 | 6.2±.7 | 7.9±.8 | .18 | .56 |
| 3-Hydroxyanthranilic acid (nM) | 58.6±0 | 41.7±13.0 | .99 | 97.8±13.7 | 108.9±23.4 | .37 | .02 |
| Hippuric acid (μM) | 3.8±.2 | 4.6±.7 | .19 | 5.6±1.9 | 4.4±.7 | .66 | .29 |
| Indoxyl sulfate (μM) | 4.6±.2 | 5.4±.5 | .19 | 5.1±.5 | 7.0±.9 | .25 | .56 |
| P-Cresyl sulfate (μM) | 1.18±.36 | 1.20±.27 | .90 | .92±.32 | .92±.46 | .79 | .56 |
All areas expressed as mean ± SEM. P values < .05 are denoted in bold.