Table 4:
Interval CRC rate among CRC-free study patients at screening compared with published studies
| Current study | National Polyp Study3,36 | Polyp Prevention Trial4,5,11 | PLCO study6 | KP 201435 | KP 201942 | |
|---|---|---|---|---|---|---|
| Procedure used | CLEAR colonoscopy | All performed by study investigators | Usual-care, community-based colonoscopy | |||
| Total patients (age, year) | 26,011 (>40) | 9,112 (NA) | 37,175 (>35 years) | 15,395 (50–75 years) | 273,742 (≥50 years) | 99,166 (50–75 years) |
| Indication | Screening | Diagnostic | Screen/diagnostic | Diagnostic | 57% diagnostic | Screening |
| Exclusions@ | 1,003 (3.9%) | 7694 (84.4%) | 35,096 (94.4%) | NA | 49,900 (18.2%) | - |
| CRC-free patients (adenoma status at screening) | 25,008 (7,530 adenoma, 17,478 no-adenoma) | 1,418 (adenoma patients) | 2,079 (adenoma patients) | 15,935 (7950 adenoma, 7985 no-adenoma) | 223,842 (all patients) | 99,166 (No-adenoma) |
| Mean age at colonoscopy (year, (SD)) | 58.1 (±9.2) | 61 (±10) | 61.0 (±0.3) | 64 (median) | 64 (median) | 55.6 |
| Interval CRCs | 67 | 5 | 14 | 196 | 712 | 184 |
| Person-Years of Observation (PYO) (mean follow-up years) | 200,834 (8.0) | 8,401 (5.9) | 7,620 (4.0) | 189,891 (119) | 927,523 (4.1) | 417,987 |
| Interval CRC/10,000 PYO a) All patients | 3.34 | - | - | 10.32 | 7.68 | - |
| b) Adenoma patients | 5.79 | 5.9 | 18.3 | 13.07 | NA | - |
| c) No adenoma | 2.24 | - | - | NA | NA | 4.4 |
| P value, Current vs Comparison study* | - | 0.95 | <0.0001 | <0.0001 | <0.0001 | 0.0004 |
| Interval CRC rate ratio | 1.0 | 1.0 | 3.2 | 3.1 | 2.3 | 2.0 |
@
See Supplementary Table 2 for the exclusion criteria applied in each study. NA: Not available for the category.
KP: Kaiser Permanente