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Normalized conductance to voltage and voltage dependence of availability relationships. Curves represent the voltage-dependence of steady-state activation (A) and voltage dependence of availability (B) in the presence (blue) and absence (black) of 100 nM 4,9-ah-TTX via whole-cell patch clamp from HEK cells stably expressing human Nav1.1, Nav1.3 or Nav1.6. (B) Data points represent the mean ± S.E. Data obtained from recordings depicted in Fig. 2.
